Aging-related decline in memory and synaptic function are associated with the dysregulation of calcium homeostasis, attributed to the overexpression of voltage-gated calcium channels (VGCC).
The membrane insertion of AMPA receptors governed by the AMPAR auxiliary proteins (TARPs) is essential for synaptic transmission and plasticity. Our results suggest that TARPγ8 may be a key molecular biomarker for brain aging and that boosting CaMKIIα-TARPγ8 signaling may be critical for the restoration of synaptic plasticity of aging and aging-related diseases. This new paper is dedicated to the memory of Dr Chris Thompson, a previous WRIHW Fellow and Biosciences Academic, who kicked off this research with Prof Paul Chazot and his postdoc, Dr Chengbiao Lu (Co-corresponding authors), nearly 20 years ago. “Everything comes to he who waits…”
JianHua, Z., Li, M., Hu, Q., Donoghue, P., Jiang, S., Li, J., Li, S., Ren, X., Zhang, Z., Du, J.,Yu, Y., Chazot, P.*, & Lu, C.* (2024). CaMKIIα-TARPγ8 Signaling mediates hippocampal synaptic impairment in aging. Aging Cell, 00, e14349. https://doi.org/10.1111/acel.14349
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