COSMA5 has approximately 300 compute nodes, each with 128GB RAM and 16 cores (2x Intel Xeon CPU E5-2670 0 @ 2.60GHz). These have a Sandy Bridge architecture.

The nodes are connected via Mellanox FDR10 Infiniband switches in a 2:1 blocking configuration. Access is enabled through two login/development servers each with 512GB of memory. Previously, there was a 2.5PB GPFS file system (DDN ExaScalar). However in early 2020, this was replaced by a 650TB Lustre system (Dell), later updated to 1.6PB, replacing 2.5 racks of equipment drawing 26kW with 1/6th of a rack drawing 1.5kW.