Staff profile

Journal Article

• Direct analysis of biotransformations with mass spectrometry—DiBT-MS
  
  Knox, R., Smith, R., Kempa, E. E., Spiess, R., Schnepel, C., Turner, N. J., Flitsch, S. L., & Barran, P. E. (2025). Direct analysis of biotransformations with mass spectrometry—DiBT-MS. Nature Protocols. Advance online publication. https://doi.org/10.1038/s41596-025-01161-9
• An engineered aldolase enables the biocatalytic synthesis of 2′-functionalized nucleoside analogues
  
  Willmott, M., Finnigan, W., Birmingham, W. R., Derrington, S. R., Heath, R. S., Schnepel, C., Hayes, M. A., Smith, P. D., Falcioni, F., & Turner, N. J. (2025). An engineered aldolase enables the biocatalytic synthesis of 2′-functionalized nucleoside analogues. Nature Synthesis, 4, 156-166. https://doi.org/10.1038/s44160-024-00671-w
• Balance between photoreduction efficiency, cofactor affinity, and allosteric coupling of halogenase flavoenzymes
  
  Diepold, N., Reese, F., Prior, T., Schnepel, C., Sewald, N., & Kottke, T. (2025). Balance between photoreduction efficiency, cofactor affinity, and allosteric coupling of halogenase flavoenzymes. Photochemical & Photobiological Sciences, 24, 37-51. https://doi.org/10.1007/s43630-024-00670-y
• The Impact of Metagenomics on Biocatalysis
  
  Hogg, B. N., Schnepel, C., Finnigan, J. D., Charnock, S. J., Hayes, M. A., & Turner, N. J. (2024). The Impact of Metagenomics on Biocatalysis. Angewandte Chemie International Edition, 63(21), Article e202402316. https://doi.org/10.1002/anie.202402316
• Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters
  
  Casamajo, A. R., Yu, Y., Schnepel, C., Morrill, C., Barker, R., Levy, C. W., Finnigan, J., Spelling, V., Westerlund, K., Petchey, M., Sheppard, R. J., Lewis, R. J., Falcioni, F., Hayes, M. A., & Turner, N. J. (2023). Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters. Journal of the American Chemical Society, 145(40), 22041-22046. https://doi.org/10.1021/jacs.3c07010
• Structure-Based Design of Small Imine Reductase Panels for Target Substrates
  
  Yu, Y., Rué Casamajo, A., Finnigan, W., Schnepel, C., Barker, R., Morrill, C., Heath, R. S., De Maria, L., Turner, N. J., & Scrutton, N. S. (2023). Structure-Based Design of Small Imine Reductase Panels for Target Substrates. ACS Catalysis, 13(18), 12310-12321. https://doi.org/10.1021/acscatal.3c02278
• Enzymatic Late‐Stage Halogenation of Peptides
  
  Schnepel, C., Moritzer, A., Gäfe, S., Montua, N., Minges, H., Nieß, A., Niemann, H. H., & Sewald, N. (2023). Enzymatic Late‐Stage Halogenation of Peptides. ChemBioChem, 24(1), Article e202200569. https://doi.org/10.1002/cbic.202200569
• Thioester-mediated biocatalytic amide bond synthesis with in situ thiol recycling
  
  Schnepel, C., Pérez, L. R., Yu, Y., Angelastro, A., Heath, R. S., Lubberink, M., Falcioni, F., Mulholland, K., Hayes, M. A., Turner, N. J., & Flitsch, S. L. (2023). Thioester-mediated biocatalytic amide bond synthesis with in situ thiol recycling. Nature Catalysis, 6(1), 89-99. https://doi.org/10.1038/s41929-022-00889-x
• One‐Step Biocatalytic Synthesis of Sustainable Surfactants by Selective Amide Bond Formation
  
  Lubberink, M., Finnigan, W., Schnepel, C., Baldwin, C. R., Turner, N. J., & Flitsch, S. L. (2022). One‐Step Biocatalytic Synthesis of Sustainable Surfactants by Selective Amide Bond Formation. Angewandte Chemie International Edition, 61(30), Article e202205054. https://doi.org/10.1002/anie.202205054
• Enzymatic Late‐Stage Modifications: Better Late Than Never
  
  Romero, E., Jones, B. S., Hogg, B. N., Rué Casamajo, A., Hayes, M. A., Flitsch, S. L., Turner, N. J., & Schnepel, C. (2021). Enzymatic Late‐Stage Modifications: Better Late Than Never. Angewandte Chemie International Edition, 60(31), 16824-16855. https://doi.org/10.1002/anie.202014931
• Novel Arylindigoids by Late‐Stage Derivatization of Biocatalytically Synthesized Dibromoindigo
  
  Schnepel, C., Dodero, V. I., & Sewald, N. (2021). Novel Arylindigoids by Late‐Stage Derivatization of Biocatalytically Synthesized Dibromoindigo. Chemistry – A European Journal, 27(17), 5404-5411. https://doi.org/10.1002/chem.202005191