Staff profile

David has over 25 years of experience addressing fundamental questions in biology such as how we age, and how we interact with bacteria, by using the the nematode worm Caenorhabditis elegans. This model system provides controlled conditions and large numbers of animals and is amenable to genetics, biochemistry and microscopy. The combination of these techniques in a whole organism is very powerful. David is also Chair of the British Society for Research on Ageing and Co-founder and Chief Scientific Officer of Magnitude Biosciences.

Bacteria and Ageing

Animals have co-evolved with microbes, so understanding these interactions is vital to understanding animal biology. The human gut microbiota is an area of intense study but it is difficult to study.

In the lab, C. elegans is cultured with the live bacteria Escherichia coli as a food source. We study both E. coli and C. elegans to understand this animal: microbe interaction.

Inhibiting folate synthesis in E. coli slows ageing in C. elegans. The levels of inhibition required to do not slowing the growth of the bacteria or the worm. Thus we propose that E. coli synthesises more folate than it needs for growth and this excess folate causes the bacteria to accelerate ageing of the animal.

We are testing this hypothesis, investigating molecular mechanisms and exploring whether folate-synthesising bacteria also accelerate human ageing.

Folic acid supplements

We have found that folic acid, the synthetic compound used to prevent folate deficiency is taken up by C. elegans via E. coli, in a pathway that relies on folic acid breakdown. We found that folic acid supplements contain breakdown products that would allow this path to be taken in humans. We still don't know the consequences for human health. Blog

Automated analysis of ageing

Together with Chris Saunter we have invented a way to automate measurements of healthspan in many large populations of worms simultaneously. We started a spinout company called Magnitude Biosciences to test drugs, supplements and other interventions to prolong healthspan.

Making therapeutic proteins

In another project, we are using C. elegans to make recombinant proteins from parasitic nematodes that could be used to treat diseases of the immune system such as asthma or rheumatoid arthritis. The intention is to enable translation to a therapy and reduce the use of lab rodents.

Current lab members (in order of appearance)

David Weinkove (LinkedIn,Twitter, Bluesky), How to pronounce Weinkove (courtesy of cousin Ben)

Adelaide Raimundo

Sushmita Maitra

Chad Yanyatan

Yinan Bu

Past lab members (other than 3^rd year undergraduate project students)

Andrea Bender, Marjanne Bourgois, James Pauw, Nikolin Oberleitner, Gonçalo Correia, Natasha Chetina, Inna Feyst, Harry Blandy, Marta Cipinska, David Bradley, Shona Lee, Noel Helliwell, Jie Jia, Razan Bakheet, Daniel Weintraub, Bhupinder Virk, Lucy Lancaster, Zoe Walmsley, Giulia Zavagno, Claire Maynard, Fiona Hair, Kasia Zmarzly, Craig Manning, James Groombridge, Giulia Zavagno, Hannah Raddings

• C. elegans
• E. coli
• Ageing
• Host:microbe interactions
• Microbial folates

• 2022: Chair of The British Society for Research on Ageing: Appointed Chair of The British Society for Research on Ageing

Chapter in book

• Imaging Fluorescent Nuclear Pore Complex Proteins in C. elegans
  
  Lancaster, C., Zavagno, G., Groombridge, J., Raimundo, A., Weinkove, D., Hawkins, T., Robson, J., & Goldberg, M. W. (2022). Imaging Fluorescent Nuclear Pore Complex Proteins in C. elegans. In The Nuclear Pore Complex. https://doi.org/10.1007/978-1-0716-2337-4_24

Journal Article

• From human to superhuman: the impact of the microbiome on physiology.
  
  Keely, S. J., Cotter, P. D., Wahlstrom, A., Schellekens, H., Weinkove, D., & Barrett, K. E. (2025). From human to superhuman: the impact of the microbiome on physiology. The Journal of Physiology, 603(4), 797-807. https://doi.org/10.1113/JP287883
• Folates, bacteria and ageing: insights from the model organism
  
  Weinkove, D. (2024). Folates, bacteria and ageing: insights from the model organism. Proceedings of the Nutrition Society. Advance online publication. https://doi.org/10.1017/S0029665124004890
• Combinations of bacterial probiotics and yeast postbiotics influence fat deposition and growth in the nematode C. elegans
  
  Fasseas, M. K., Maitra, S., Tintoré, M., Cuñé, J., de Lecea, C., & Weinkove, D. (2024). Combinations of bacterial probiotics and yeast postbiotics influence fat deposition and growth in the nematode C. elegans. PharmaNutrition, 29, Article 100404. https://doi.org/10.1016/j.phanu.2024.100404
• Timut Pepper Extract Slows Age-Dependent Decline of Mobility and Collagen Loss and Promotes Longevity.
  
  Jongsma, E., Grigolon, G., Baumann, J., Weinkove, D., Ewald, C. Y., Wandrey, F., & Grothe, T. (2024). Timut Pepper Extract Slows Age-Dependent Decline of Mobility and Collagen Loss and Promotes Longevity. Nutrients, 16(13), Article 2122. https://doi.org/10.3390/nu16132122
• Rapid measurement of ageing by automated monitoring of movement of C. elegans populations
  
  Zavagno, G., Raimundo, A., Kirby, A., Saunter, C., & Weinkove, D. (2024). Rapid measurement of ageing by automated monitoring of movement of C. elegans populations. GeroScience, 46, 2281–2293. https://doi.org/10.1007/s11357-023-00998-w
• New tools to monitor Pseudomonas aeruginosa infection and biofilms in vivo in C. elegans
  
  Xue, F., Ragno, M., Blackburn, S. A., Fasseas, M., Maitra, S., Liang, M., Rai, S., Mastroianni, G., Tholozan, F., Thompson, R., Sellars, L., Hall, R., Saunter, C., Weinkove, D., & Ezcurra, M. (2024). New tools to monitor Pseudomonas aeruginosa infection and biofilms in vivo in C. elegans. Frontiers in Cellular and Infection Microbiology, 14, Article 1478881. https://doi.org/10.3389/fcimb.2024.1478881
• Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans
  
  Reigada, I., Kapp, K., Maynard, C., Weinkove, D., Valero, M. S., Langa, E., Hanski, L., & Gómez-Rincón, C. (2022). Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans. Nutrients, 14(9), Article 1986. https://doi.org/10.3390/nu14091986
• Applying C. elegans to the Industrial Drug Discovery Process to Slow Aging
  
  Weinkove, D., & Zavagno, G. (2021). Applying C. elegans to the Industrial Drug Discovery Process to Slow Aging. Frontiers in Aging, 2, Article 740582. https://doi.org/10.3389/fragi.2021.740582
• Jasonia glutinosa (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different In Vitro and In Vivo Systems
  
  Les, F., Valero, M. S., Moliner, C., Weinkove, D., López, V., & Gómez-Rincón, C. (2021). Jasonia glutinosa (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different In Vitro and In Vivo Systems. Biology, 10(5), Article 443. https://doi.org/10.3390/biology10050443
• Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety
  
  Tataridas-Pallas, N., Thompson, M. A., Howard, A., Brown, I., Ezcurra, M., Wu, Z., Silva, I. G., Saunter, C. D., Kuerten, T., Weinkove, D., Blackwell, T. K., & Tullet, J. M. (2021). Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety. PLOS Genetics, 17(3), Article e1009358. https://doi.org/10.1371/journal.pgen.1009358
• Bacteria increase host micronutrient availability: mechanisms revealed by studies in C. elegans
  
  Maynard, C., & Weinkove, D. (2020). Bacteria increase host micronutrient availability: mechanisms revealed by studies in C. elegans. Genes & Nutrition, 15, Article 4. https://doi.org/10.1186/s12263-020-00662-4
• Antioxidant and Antiaging Effects of Licorice on the Caenorhabditis elegans Model
  
  Reigada, I., Moliner, C., Valero, M. S., Weinkove, D., Langa, E., & Gómez Rincón, C. (2020). Antioxidant and Antiaging Effects of Licorice on the Caenorhabditis elegans Model. Journal of Medicinal Food, 23(1). https://doi.org/10.1089/jmf.2019.0081
• A bacterial route for folic acid supplementation
  
  Maynard, C., Cummins, I., Green, J., & Weinkove, D. (2018). A bacterial route for folic acid supplementation. BMC Biology, 16, Article 67. https://doi.org/10.1186/s12915-018-0534-3
• Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy
  
  Lundquist, M. R., Goncalves, M. D., Loughran, R. M., Possik, E., Vijayaraghavan, T., Yang, A., Pauli, C., Ravi, A., Verma, A., Yang, Z., Johnson, J. L., Wong, J. C., Ma, Y., Hwang, K. S., Weinkove, D., Divecha, N., Asara, J. M., Elemento, O., Rubin, M. A., … Emerling, B. M. (2018). Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Molecular Cell, 70(3), 531-544.e9. https://doi.org/10.1016/j.molcel.2018.03.037
• On microbes, aging and the worm: an interview with David Weinkove
  
  Weinkove, D. (2018). On microbes, aging and the worm: an interview with David Weinkove. BMC Biology, 16(1), Article 125. https://doi.org/10.1186/s12915-018-0600-x
• WormJam: A consensus C. elegans Metabolic Reconstruction and Metabolomics Community and Workshop Series
  
  Hastings, J., Mains, A., Artal-Sanz, M., Bergmann, S., Braeckman, B. P., Bundy, J., Cabreiro, F., Dobson, P., Ebert, P., Hattwell, J., Hefzi, H., Houtkooper, R. H., Jelier, R., Joshi, C., Kothamachu, V. B., Lewis, N., Lourenço, A. B., Nie, Y., Norvaisas, P., … Casanueva, O. (2017). WormJam: A consensus C. elegans Metabolic Reconstruction and Metabolomics Community and Workshop Series. Worm, 6(2), Article e1373939. https://doi.org/10.1080/21624054.2017.1373939
• Folate acts in E. coli to accelerate C. elegans aging independently of bacterial biosynthesis
  
  Virk, B., Jia, J., Maynard, C., Raimundo, A., Lefebvre, J., Richards, S., Chetina, N., Liang, Y., Helliwell, N., Cipinska, M., & Weinkove, D. (2016). Folate acts in E. coli to accelerate C. elegans aging independently of bacterial biosynthesis. Cell Reports, 14(7), 1611-1620. https://doi.org/10.1016/j.celrep.2016.01.051
• Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children
  
  Zhang, C., Yin, A., Li, H., Wang, R., Wu, G., Shen, J., Zhang, M., Wang, L., Hou, Y., Ouyang, H., Zhang, Y., Zheng, Y., Wang, J., Lv, X., Wang, Y., Zhang, F., Zeng, B., Li, W., Yan, F., … Zhao, L. (2015). Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children. EBioMedicine, 2(8), 968-984. https://doi.org/10.1016/j.ebiom.2015.07.007
• From aging worms to the influence of the microbiota: an interview with David Weinkove
  
  Weinkove, D. (2013). From aging worms to the influence of the microbiota: an interview with David Weinkove. BMC Biology, 11. https://doi.org/10.1186/1741-7007-11-94
• Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism
  
  Cabreiro, F., Au, C., Leung, K., Vergara-Irigaray, N., Cochemé, H., Noori, T., Weinkove, D., Schuster, E., Greene, N., & Gems, D. (2013). Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell, 153(1), 228-239. https://doi.org/10.1016/j.cell.2013.02.035
• Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model
  
  Virk, B., Correia, G., Dixon, D., Feyst, I., Jia, J., Oberleitner, N., Briggs, Z., Hodge, E., Edwards, R., Ward, J., Gems, D., & Weinkove, D. (2012). Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model. BMC Biology, 10(1), Article 67. https://doi.org/10.1186/1741-7007-10-67
• A casein kinase 1 and PAR proteins regulate asymmetry of a PIP2 synthesis enzyme for asymmetric spindle positioning
  
  Panbianco, C., Weinkove, D., Zanin, E., Jones, D., Divecha, N., Gotta, M., & Ahringer, J. (2008). A casein kinase 1 and PAR proteins regulate asymmetry of a PIP2 synthesis enzyme for asymmetric spindle positioning. Developmental Cell, 15(2), 198-208. https://doi.org/10.1016/j.devcel.2008.06.002
• Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults
  
  Weinkove, D., Bastiani, M., Chessa, T., Joshi, D., Hauth, L., Cooke, F., Divecha, N., & Schuske, K. (2008). Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults. Developmental Biology, 313(1), 384-397. https://doi.org/10.1016/j.ydbio.2007.10.029
• Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans
  
  Bass, T., Weinkove, D., Houthoofd, K., Gems, D., & Partridge, L. (2007). Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mechanisms of Ageing and Development, 128(10), 546-552. https://doi.org/10.1016/j.mad.2007.07.007
• Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm
  
  Weinkove, D., Halstead, J., Gems, D., & Divecha, N. (2006). Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm. BMC Biology, 4, Article 1. https://doi.org/10.1186/1741-7007-4-1
• The G-protein gamma subunit gpc-1 of the nematode C. elegans is involved in taste adaptation
  
  Jansen, G., Weinkove, D., & Plasterk, R. (2002). The G-protein gamma subunit gpc-1 of the nematode C. elegans is involved in taste adaptation. EMBO Journal, 21(5), 986-994. https://doi.org/10.1093/emboj/21.5.986
• The genetic control of organ growth: insights from Drosophila
  
  Weinkove, D., & Leevers, S. (2000). The genetic control of organ growth: insights from Drosophila. Current Opinion in Genetics and Development, 10(1), 75-80. https://doi.org/10.1016/s0959-437x%2899%2900042-8
• Regulation of imaginal disc cell size, cell number and organ site by Drosophila class I-A phosphoinositide 3-kinase and its adaptor
  
  Weinkove, D., Neufeld, T., Twardzik, T., Waterfield, M., & Leevers, S. (1999). Regulation of imaginal disc cell size, cell number and organ site by Drosophila class I-A phosphoinositide 3-kinase and its adaptor. Current Biology, 9(18), 1019-1029. https://doi.org/10.1016/s0960-9822%2899%2980450-3
• Mutants of Phycomyces with decreased gallic acid content
  
  Weinkove, D., Poyatos, J., Greiner, H., Oltra, E., Avalos, J., Fukshansky, L., Barrero, A., & Cerda-Olmedo, E. (1998). Mutants of Phycomyces with decreased gallic acid content. Fungal Genetics and Biology, 25(3), 196-203. https://doi.org/10.1006/fgbi.1998.1098
• p60 is an adaptor for the Drosophila phosphoinositide 3-kinase, Dp110
  
  Weinkove, D., Leevers, S., MacDougall, L., & Waterfield, M. (1997). p60 is an adaptor for the Drosophila phosphoinositide 3-kinase, Dp110. Journal of Biological Chemistry, 272(23), 14606-14610. https://doi.org/10.1074/jbc.272.23.14606
• The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth
  
  Leevers, S., Weinkove, D., MacDougall, L., Hafen, E., & Waterfield, M. (1996). The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO Journal, 15(23), 6584-6594.

Other (Print)

• Model Super-organisms: Can the biochemical genetics of E. coli help us understand aging?
  
  Weinkove, D. (2015). Model Super-organisms: Can the biochemical genetics of E. coli help us understand aging? The Biochemist.