Thesis Prize
This annual prize celebrates Durham's interdisciplinary postgraduate students. The prize focusses on students who have applied creativity and initiative to their research, particularly those who have driven the research far beyond expectations.
The assessment takes into account the excellence of the science included in the nominee's thesis as well as their development as a research with the skills and breadth of knowledge needed for interdisciplinary research.
2024 Winner: Dr Josh Hughes
12-1.30 pm, Penthouse, Collingwood College
Biological and photophysical analysis of novel diaryl acetylene photosensitisers for the treatment of oral epithelial dysplasia
Abstract: Oral cancer is the sixth most common cancer worldwide. Diagnosis often occurs in the later stages of disease progression, significantly contributing to a survival rate of less than 50% over five years. The conventional treatment methods—surgery and radiotherapy—are highly invasive and greatly impact patients' quality of life. Photosensitisers offer a highly targeted, non-invasive treatment option for cancerous and precancerous lesions, either as an alternative to or in combination with established procedures.
LightOx has developed a novel class of donor-acceptor diaryl acetylene photosensitisers. The structural variations in the donor and acceptor groups influence lipophilicity, induced charge transfer, cellular localisation, and phototoxicity. Compounds with minimal charge-transfer characteristics, coupled with heavy atoms such as the sulfur atom in thiophene groups, proved to be the most potent. Furthermore, non-polar, lipophilic environments were optimal for inducing phototoxicity in this class of photosensitisers.
The 2024 Thesis prize will be held in our BSI Lunchtime Seminar slot, the final session before Christmas. To attend please complete the form below for catering purposes.
Register here: https://forms.office.com/e/yUinm9G2zc
Making a nomination for 2025
To make a nomination please send the following to admin.bsi@durham.ac.uk
- Thesis abstract
- Letter of support (maximum of one page of A4)
- Minimum of two expert reports from outside the supervisory team (e.g. examiner's report)
- List of publications and presentations associated with the nominee's thesis
- Nominee's CV
Criteria
Nominees for 2025 must submit their thesis at Durham University between June 2024 and June 2025.
A large portion of the nominee's research must be cross-disciplinary at the boundaries between the life sciences and other physical sciences including mathematical sciences and engineering.
The prize consists of a £500 payment and prize certificate. The presentation of the prize will be made at the BSI's Annual Summer Showcase.
Evaluation of nominations will look for:
1. Outstanding performance of the student and their development as a researcher
2. Impact on the field as evidenced by the nomination materials
3. Quality of the cross-disciplinary aspect of the research: was the approach relevant and well-considered.
Please contact bsi.manager@durham.ac.uk for further details on criteria and application requirements.
Closing date: 27 June 2025
Previous Thesis Prize Winners
2023 Thesis Prize
Fantastic proteins and where to find them, Dr Katy Cornish
2022 Thesis Prize
Slowing down to get ahead: functional and structural characterisation of toxin-antitoxin systems from Mycobacterium tuberculosis, Dr Ben Usher
2021 Thesis Prize
The Impact of Dynamics in Protein Assembly, Dr Lucas Rudden
2018 Thesis Prize
Exploring the applications of fluorine for peptoid structure induction, Dr Diana Gimenez