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Overview
Affiliations
AffiliationTelephone
Professor in the Department of Biosciences+44 (0) 191 33 43983
Professor in the Department of Chemistry+44 (0) 191 33 43983
Fellow of the Wolfson Research Institute for Health and Wellbeing43983

Biography

Protozoan parasites are the causative agents of a wide range of important human and animal diseases, including malaria. Current work in Paul's laboratory is focused on furthering the understanding of the role of lipid biosynthesis and membrane trafficking in host-pathogen interactions, with a view to elucidating protozoan specific activities amenable to therapeutic intervention. Previous to his appointment in 2004 Paul worked in research posts at Imperial College London and at the Medical Research Council's National Institute for Medical Research.

1. Protozoan sphingolipid biosynthesis (with Prof Ehmke Pohl and others)

2. Antileishmanial discovery (with Prof Patrick Steel and others)

3. Antileishmanial mode of action deconvolution (with GSK and others)

 

Research interests

  • Cell Biology
  • Lipid Biochemistry
  • Molecular Biology
  • Parasitology

Esteem Indicators

  • 2024: MRC Outstanding Team Impact Prize Winner - Lead: Global Network for NTDs The MRC Global Challenges Research Fund-funded Global Network for NTDs brought together over 500 researchers from 13 institutes around the world, via new collaborative research teams focused on Leishmaniasis and Chagas disease. The network sought to democratise and decolonise the field, through growing laboratory research capacity and expertise in endemic countries across Asia and South America. It has made significant scientific advances. Its cross-disciplinary partnerships with endemic country scientists have demonstrated globally equitable working practices. This exemplar brought in and influenced private sector collaborators, revealing the network’s most tangible legacy and impact.
  • 2023: Fellow of the Royal Society of Biology: Elected January 2023
  • 2022: Topic Editor: Frontiers in Cellular and Infection Microbiology, section Parasite and Host

     Leishmania Genome Variability: Impacts on Parasite Evolution, Parasitism and Leishmaniases Control

  • 2018: Editorial Board Member, Parasitology (CUP):
  • 2018: Invited Presentation: CSIR-CDRI, Lucknow, India
  • 2018: Invited Presentation: CSIR-IICB TRUE, Kolkata, India
  • 2018: Key Note Address: CSIR-IICB, Jadavpur Campus, Kolkata, India
  • 2016: Elected Office: Honorary Treasurer of Council of British Society for Parasitology (2016-19)
  • 2013: Elected Office: Member of Council of British Society for Parasitology
  • 2013: Invited Review: The utility of yeast as a tool for cell-based, target-directed high-throughput screening, J.L. Norcliffe, E. Alvarez-Ruiz, J.J. Martin-Plaza, P.G. Steel, P.W. Denny

  • 2012: Presentation at International Meeting: Screening for inhibitors of the Leishmania IPC synthase, BSP-RSC Emerging Paradigms in Anti-Infective Drug Design, LSHTM London (September 2012)
  • 2012: Guest Editor: Special edition of Biochemistry Research International: Lipid Metabolism as a Therapeutic Target
  • 2011: Invited Presentation: Open Lab Foundation, Governing Board Meeting, GSK Tres Cantos, Madrid
  • 2011: Invited Seminar: Spingolipid synthesis and scavenging in the parasitic protozoa (June 2011), Institut für Virologie, Zentrum für Hygiene und Infektionsbiologie, Philipps-Universität Marburg

Publications

Journal Article

Newspaper/Magazine Article

Other (Digital/Visual Media)

Other (Print)

Patent

Supervision students